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Simultaneous kinetic spectrophotometric determination of cephalexin and trimethoprim in pharmaceutical preparation and human urine with the aid of chemometrics

机译:化学计量学同时动力学分光光度法测定药物制剂和人尿中的头孢氨苄和甲氧苄啶

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摘要

为 cephalexin 和 trimethoprim 的同时的运动 spectrophotometric 决心的一个过程被描述。它与黄铵 cerous (IV ) 基于这些混合物的氧化的不同反应率在酸的中等、无色的 cerous (III ) 的硫酸盐硫酸盐被生产。重叠运动数据是 chemometric 方法的使用解决的份量上,部分最少的广场(请) ,主要部件回归(PCR ) 和光线的基础功能人工的神经网络(RBF-ANN ) 。建议方法也与满足的结果在药品的准备和人的尿被用于 cephalexin 和 trimethoprim 的同时的决心,它与那些由 HPLC 获得了作比较很好。
机译:A procedure for the simultaneous kinetic spectrophotometric determination of cephalexin and trimethoprim was described. It was based on the different reaction rate of oxidation of these compounds with yellow ammonium cerous (Ⅳ) sulfate in acidic medium and colorless cerous (Ⅲ) sulfate was produced. The overlapped kinetic data was quantitatively resolved by the use of chemometric methods, partial least squares (PLS), principal component regression (PCR) and radial basis function-artificial neural network (RBF-ANN). The proposed method was also applied to the simultaneous determination of cephalexin and trimethoprim in pharmaceutical preparation and human urine with satisfied results, which compared well with those obtained by HPLC.

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