Studies on Agarofurans V. Studies on the Reductive Ring-Opening of 3,4-Epoxide of Agarofurans

摘要

Reduction of epoxides 1, 2, 3 with LAH and LAH/AlCl3 has been studied. The products of reduction with LAH were controlled by steric and stereoelectronic effects. The reduction with LAH/AlCl3 seemed to involve an intermediate in which one aluminum ion was shared by both oxygen atoms from the epoxide and the tetrahydrofuran ring.