A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR,1H NMR, and HRMS(ESI). Preliminary bioassay showed that some compounds, 5b and 5g, exhibited good activity against soybean aphids(Aphis glycines) at 100 mg L 1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.
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