不同剂量阿托伐他汀治疗老年冠状动脉粥样硬化性心脏病的疗效与并发症观察

摘要

Objective To observe the effect and complications of different doses of atorvastatin in treating senile coronary atherosclerosis heart disease. Methods 128 cases of senile coronary heart disease (CHD) were randomly divided into the eXperimental group and the control group, 64 cases in each group. On the basis of the conventional treatment the control group took oral atorvastatin 15 mg each time, while the eXperimental group took atorvastatin 30 mg each time. Both groups took atorvastatin once a day, with the treatment course of 5 months. The differences of HDL - C, TC, LDL - C, Tg, HS - CRP levels before and after treatment were compared between the two groups; the complications within 5 months were also compared between the two groups. The clinical curative effects were analyzed in the two groups. Results The TC, LDL - C, Tg and hs - CRP levels after treatment were significantly decreased in the two groups( P < 0. 05), but the decrease in the eXperimental group was more significant, the difference between the two groups had statistical significance ( P < 0. 05 ); the HDL - C level, complications and their occurrence rates within 5 months had no statistically significant difference be-tween the two groups. No severe complications occurred in the two groups. Conclusion Adopting larger dose of atorvastatin for treating senile CHD has no obvious aggravation of complications, can effectively improve the inflammatory factors, decrease blood fat and relieve the cardiovascular events occurrence.%目的：观察不同剂量阿托伐他汀治疗老年冠状动脉粥样硬化性心脏病的疗效及并发症。方法随机将128例老年冠心病患者分为试验组和对照组，每组64例。在常规治疗基础上，对照组口服阿托伐他汀15 mg /次；治疗组口服阿托伐他汀30 mg /次，两组服用阿托伐他汀均每天1次，疗程为5个月。比较两组治疗前后高密度脂蛋白胆固醇(HDL － C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL － C)、三酰甘油(Tg)、血清高敏 C 反应蛋白(hs － CRP)水平差异；比较5个月内两组并发症。分析两组临床治疗效果。结果治疗后两组 TC， LDL － C，Tg，hs － CRP 水平均显著降低( P <0.05)，但试验组降低更明显( P <0.05)；5个月内，试验组与对照组 HDL － C 水平、并发症及发生率无明显差异，且无严重并发症。结论老年冠心病患者采用较大剂量阿托伐他汀记录，并发症无明显加重，且还可有效改善炎症因子水平，调节血脂，降低心血管事件的发生。