目的：观察射干提取物用于慢性咽炎家兔血清中白细胞介素－4（IL－4）和免疫球蛋白E ( IgE )指标的变化，以进一步探讨其治疗作用机制。方法应用氨水和松节油直接作用于大耳白家兔咽部黏膜制备慢性咽炎病理模型，以射干提取物进行治疗，观察药物对模型动物血清IL－4和IgE表达的影响。结果模型组动物血清中的IL－4和IgE含量显著高于空白组（ P<0．05），经射干提取物治疗后血清中IL－4和IgE水平均较模型组降低。结论射干治疗慢性咽炎药理活性作用可能是通过调节细胞因子的表达而实现的。%Objective To study the expression of interleukin-4 and IgE in the pharyngitis rabbit model with the Rhizoma Belamcandae extracts to explore its treatment mechanism. Methods White rabbits were used in this study to prepare the model of chronic pharyngi-tis, induced by directly applied into the pharyngeal mucosa with ammonia water and turpentine oil at first. Then, these modeling animals were divided into several groups, with the Rhizoma Belamcandae extracts taken to treat this kind of lesion. The changes in the expres-sion of IL-4 and IgE of these animal models were determined to evaluate the pharmacological effects of this solution on the le-sion. Results It was shown that the level of IL-4 and IgE were reduced among the animals in treating group ( P < 0. 05 ) . Conclusion The therapeutic mechanisms of Rhizoma Belamcandae extracts or the treatment of chronic pharyngitis may be achieved by regulating the expression of cytokines.
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