氟桂利嗪联合血塞通治疗老年偏头痛68例疗效及安全性评价

摘要

目的：探讨氟桂利嗪联合血塞通治疗老年偏头痛的临床疗效及安全性。方法将136例老年偏头痛患者按随机数字表法分为研究组和对照组，对照组给予氟桂利嗪治疗，研究组给予氟桂利嗪联合血塞通治疗，比较两组临床疗效及不良反应。结果研究组和对照组患者治疗前后的发作次数[(8.11±0.93)次／月比(25.58±2.55)次／月，(14.30±1.55)次／月比(25.28±2.71)次／月]和疼痛程度评分[VAS 评分，(1.36±0.12)分比(4.53±0.61)分，(2.82±0.32)分比(4.62±0.48)分]，均较治疗前明显下降，而发作持续时间[(3.36±0.41)h比(11.41±1.36)h，(6.43±0.60)h比(11.29±1.41)h]则较治疗前明显缩短（P﹤0.05）。研究组患者治疗后的发作次数、疼痛程度评分及发作持续时间等均较对照组治疗后明显改善（ P﹤0.05）；治疗总有效率为91.18%，明显高于对照组的72.06%（ P﹤0.05）。研究组不良反应发生率与对照组比较无明显差异（10.29%比8.82%，P﹥0.05）。结论采用氟桂利嗪联合血塞通治疗老年偏头痛疗效优于单用氟桂利嗪，无明显不良反应，值得推广。%Objective To investigate the clinical efficacy of flunarizine combined with Xuesaitong in the treatment of elderly migraine. Methods 136 cases of elderly migraine patients were divided into study group and control group according to random number table method. The control group was given alone flunarizine treatment, while the study group received flunarizine combined with Xue-saitong. The clinical therapeutic effect and adverse reaction were compared between the two group. Results The number of episodes in the study group and the control group after treatment were [ ( 8. 11 ± 0. 93 ) times/month vs ( 25. 58 ± 2. 55 ) times/month, ( 14. 30 ± 1. 55 ) times/month ratio ( 25. 28 ± 2. 71 ) times/month ] , and pain severity score [ VAS score, ( 1. 36 ± 0. 12 ) points vs ( 4. 53 ± 0. 61 ) points, ( 2. 82 ± 0. 32 ) points vs ( 4. 62 ± 0. 48 ) points ] were both significantly decreased than before treatment, while the duration of attack [ ( 3. 36 ± 0. 41 ) h vs ( 11. 41 ± 1. 36 ) h, ( 6. 43 ± 0. 60 ) h vs ( 11. 29 ± 1. 41 ) h ] were significantly shorter than before treatment ( P ﹤0. 05 ) . The number of episodes, the onset of pain score and duration in the study group improved significantly than those in the control group after treatment ( P ﹤ 0. 05 );the total effective rate was 91. 18%, which was significantly higher than 72. 06% of the control group ( P ﹤ 0. 05 ) . The incidence of adverse reactions in the study group showed no significant difference with the control group ( 10. 29%vs 8. 82% , P ﹥ 0. 05 ) . Conclusion Flunarizine combined with Xuesaitong elderly migraine curative efficacy is better than that of treatment with flunarizine, without obvious adverse reaction, which is worthy of clinical promotion.