某社区卫生服务中心140例药品不良反应分析

摘要

目的 分析某社区卫生服务中心140例药品不良反应(ADR)报告,为基层社区医务人员临床安全、合理用药提供参考.方法 收集2014年至2016年该中心上报的ADR病例报告,从性别和年龄分布用药情况等进行统计分析.结果 140例ADR患者中,男54例(38.57%),女86例(61.43%),男女比例为1:1.59;61岁以上的老年人ADR构成比最高(占60.00%);抗微生物药物ADR构成比最高,为68例(48.57%);静脉给药ADR构成比最高(占52.86%).ADR累及的器官/系统主要是皮肤及附件损害(38.92%)和消化系统损害(17.84%)为主.新的严重及严重的ADR 17例(12.14%),主要为抗微生物药物.结论 基层社区医务人员应进一步加强抗微生物药物的ADR监测及静脉给药监管措施.%Objective To analyze 140 reports of adverse drug reactions ( ADRs ) in a community health service center and to provide refer-ence for clinical safety and rational use of drugs in grassroots community medical staffs. Methods ADR reports collected from the center by the ADR monitoring center from 2014 to 2016, the gender and age distribution and medication situation were analyzed statistically. Results In 140 ADR reports, there were 54 males ( 38. 57% ) and 86 females ( 61. 43% ) , with ratio of 1 :1. 59. The incidence rate of ADRs was the highest in over 61 years old patients ( accounting for 60. 00%) . The ratio of ADRs caused by antimicrobial drugs was the highest (68 cases, accounting for 48. 57%). The ratio of ADRs caused by intravenous drip was the highest (accounting for 52. 86%). Organs/systems involved in ADRs were main the lesion of skin and appendants ( 38. 92% ) and the damages of gastrointestinal system ( 17. 84% ) . There were 17 cases ( 12. 14% ) of new serious ADRs and serious ADRs, which were mainly induced by antimicrobial drugs. Conclusion Medical staffs in grassroots community should strengthen the ADR monitoring of antimicrobial drugs and supervisory measures of intravenous drip.