乌拉地尔和多巴酚丁胺的配伍稳定性考察

摘要

Objective To investigate the compatible stability of Urapidil Injection and Dobutamine Injection. Methods The Urapidil Injection and Dobutamine Injection were dissolved into 0. 9％ Sodium Chloride Injection by clinical drug concentration. The contents of urapidil and dobutamine in mixture were determined by HPLC at different time, at the same time, the pH and appearance of the solution were also investigated. Results There was no significant difference in the content, pH and appearance changes after the compatibility of the two drugs within 12 h( P > 0. 05). Conclusion The compatibility of Urapidil Injection and Dobutamine Injection was stable within 12 h, which can be used in clinic.%目的 考察乌拉地尔与多巴酚丁胺的配伍稳定性.方法 将乌拉地尔注射液与多巴酚丁胺注射液按临床用药浓度溶于0.9％氯化钠注射液中,用高效液相色谱法测定其在不同配伍时间乌拉地尔和多巴酚丁胺的含量,同时考察配伍溶液的pH和外观.结果 在12 h内,2种药物配伍后的含量、pH及外观变化均无显著差异(P>0.05).结论 乌拉地尔注射液和多巴酚丁胺注射液12 h内的配伍性质稳定,临床可配伍使用.