目的 探讨老年患者对比剂肾病(CIN)的发生率与心脏-脚踝血管指数(CAVI)间的关系.方法 对60岁及以上行经皮冠状动脉介入(PCI)的患者264例,进行CAVI测定,并分为CAVI≥9.0组(122例)及CAVI＜9.0组(142例),2组患者分别于术前和术后24,48 h行血清肌酐(SCr)及BUN测定及相应的生化检查,根据CockcroftGault公式计算出内生肌酐清除率(Ccr).对2组患者造影前后各项指标的变化及CIN的发生率进行比较.结果 2组患者使用对比剂24～48 h后SCr均有明显升高,Ccr明显降低,CAVI≥9.0组变化更明显,差异均有统计学意义(P＜0.05或P＜0.01),并且CIN的发生率高(6.56%比2.27%,P＜0.05).结论 CAVI增高与CIN的发生有一定的相关性,可作为介入术前评估CIN风险的一项指标.%Objective To investigate the relation between Cardio-ankle vascular index ( CAVI) and incidence of radiographic contrast nephropathy in senile patients after coronary angiography. Methods Two hundreds and sixty-four cases over 60 years were divided into two groups according to the value of CAVI. Serum creatinine and blood urea nitrogen and chemical inspection were measured before coronary angiography (CA) and on the 1st and 2nd days after CA. Results The value of serum creatinine and blood urea nitrogen 24 h and 48 h after CA in CAVI ≥9.0 group were increased (P<0.05) than those in CAVI <9.0 group. The occurrence of radiographic contrast nephropathy in CAVI ≥9.0 group was higher than that in CAVI <9.0 group. Conclusion CAVI is a risk factor of the incidence of radiographic contrast nephropathy in senile patients after CA.
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