奥美拉唑联合用药治疗以咳嗽为主要表现的胃食管反流病的效果观察

摘要

Objective To discuss the clinical effect of omeprazole combination treating cough caused by gastroesophageal reflux.Methods Totally 50 cases of gastroesophageal reflux of Tieying hospital of Fengtai district in Beijing city from March 2012 to March 2013 were randomly selected and divided into observation group and control group; each group had 25 cases.The control group was given omeprazole; observation group was given ranitidine,motilium,sucralfate based on the treatment of control group.The total effect rate,reflux times more than 5 min,the longest reflux time and the percentage of pH ＜ 4 were compared.Results The total effect of observation group (96.0％) was significantly higher than that of the control group (68.0％) (P ＜ 0.05).There were significant differences on regarding detection of esophageal pH ＜ 4,reflux times more than 5 min,the longest reflux time and percentage of pH ＜ 4 between two groups after treatment [observation group:(36 ± 13) times,(2.0 ± 1.1) times,(14 ± 12) min,(6 ± 3) ％ ; control group:(45 ± 16) times,(2.7 ± 1.2) time,(17 ± 11) min,(7 ± 5) ％] compared with before treatment [observation group:(79 ± 12) times,(5.7 ± 2.2) times,(38 ± 16) min,(18 ± 7) ％ ;control group:(78 ± 16) times,(5.9 ± 2.9) times,(36 ± 12) min,(20 ± 7) ％] (P ＜ 0.05).Times of esophageal pH ＜ 4,reflux times more than 5 min,the longest reflux time and percentage of pH ＜ 4 in observation group were significantly lower than those in the control group (P ＜ 0.05).Conclusion Omeprazole combination in the treatment of cough caused by gastroesophageal reflux is effective.%目的 探讨奥美拉唑联合用药治疗以咳嗽为主要表现的胃食管反流病的临床疗效.方法 选取2012年3月至2013年3月北京市丰台区铁营医院诊治的以咳嗽为主要表现的胃食管反流病患者50例,用随机数字表法分为观察组和对照组,每组25例.对照组服用奥美拉唑胶囊,观察组在对照组的基础上加服雷尼替丁、多潘立酮、硫糖铝悬液.比较2组总有效率以及食管pH值＜4次数、反流超过5 min次数、最长反流持续时间、pH值＜4时间占总监测时间的百分率.结果 观察组总有效率为96.0％,明显高于对照组68.0％,差异有统计学意义(P＜0.05).2组治疗后pH ＜4次数、反流超过5 min次数、最长反流时间、pH值＜4的时间占总监测时间的百分比[观察组:(36±13)次、(2.0±1.1)次、(14±12) min、(6±3)％；对照组:(45±16)次、(2.7±1.2)次,(17±11)min、(7±5)％]与治疗前[观察组:(79±12)次、(5.7±2.2)次、(38 ± 16) min、(18±7)％；对照组:(78±16)次、(5.9±2.9)次、(36±12) min、(20±7)％]比较,差异均有统计学意义(均P＜0.05).观察组治疗后pH ＜4次数、反流超过5 min次数、最长反流时间、pH值＜4的时间占总监测时间的百分比均明显低于对照组(P＜0.05).结论 奥美拉唑联合用药治疗以咳嗽为主要表现的胃食管反流病疗效确切.