肿瘤临终患者并发上消化道出血的相关因素分析

摘要

目的 分析肿瘤临终患者发生上消化道出血的危险因素.方法 选择2006年9月至2011年2月在北京老年医院住院的164例肿瘤临终患者,对86例并发上消化道出血病例(观察组)与78例未并发上消化道出血病例(对照组)的性别、年龄、幽门螺杆菌(Hp)感染、非甾体类抗炎药的使用、Hb水平以及应激状态、长期心肺疾病的存在进行比较分析.结果 Logistic多因素逐步回归分析显示:Hp感染[比值比(OR)=4.228,95％置信区间(CI)为2.019～8.851]、非甾体类抗炎药的应用(OR=3.547,95％ CI为1.674～7.516)、应激状态(OR =2.433,95％ CI为1.146 ～5.165)、长期心肺疾病(OR=2.805,95％ CI为1.313～5.992)与肿瘤临终患者并发上消化道出血有相关性(均P＜0.05).结论 加强肿瘤临终患者上消化道出血的监控,重视危险因素,早期预防和治疗,提高生活质量.%Objective To investigate risk factors of upper gastrointestinal bleeding in hospice inpatients.Methods The clinical data of 86 inpatients with upper gastrointestinal bleeding (experimental group) was retrospectively compared with 78 cases of non-upper gastrointestinal bleeding cases (control group).Results Multivariate Logistic stepwise regression analysis showed that helilcobactor pylori infection [odds ratios(OR) =4.228,95％confidence interval(CI) was 2.019-8.851],non-steroidal anti-inflammatory drugs (OR =3.547,95％ CI was 1.674-7.516),stress (OR =2.433,95％ CI was 1.146-5.165),long-term heart and lung disease (OR =2.805,95 ％ CI was 1.313-5.992) were associated with hospice inpatients of upper gastointestinal bleeding (P ＜ 0.05).Conclusion We should enhance surveillance inpatients with gastrointestinal bleeding in order to improve the quality of life.