层粘连蛋白4亚基表达对早期喉癌侵袭性与转移性的影响

摘要

目的 探讨层粘连蛋白4亚基(LAMA4)表达对早期喉癌侵袭性与转移性的影响.方法 选择2011年7月至2014年12月在深圳市福田区人民医院接受治疗的原发性喉鳞状细胞癌患者66例,通过手术方法取得癌组织与癌旁组织,对LAMA4表达进行免疫组织化学检测,分析LAMA4在癌组织与癌旁组织的表达及其与年龄、性别、病灶位置、临床分期、分化程度、淋巴结转移的相关性.结果 LAMA4在癌组织中的阳性表达率为48.5％(32/66),在癌旁组织中的阳性表达率为86.4％(57/66),LAMA4阳性表达率在癌旁组织明显高于癌组织,差异有统计学意义(P＜0.05).LAMA4阳性表达与喉癌患者的临床分期、分化程度、淋巴结转移情况相关(x2 =7.984、6.309、4.092,P＜0.05),而与喉癌的病灶位置、性别及年龄不相关(P＞0.05).结论 LAMA4在早期喉癌中低表达,对喉癌组织的侵袭和转移有抑制作用.%Objective To investigate the influence of laminins α4 (LAMA4) expression on invasion and metastasis of early laryngeal.Methods Sixty six patients with primary laryngeal squamous cell carcinoma from July 2011 to December 2014 were selected.The carcinoma and adjacent tissues were obtained during surgery to detect the expression of LAMA4 by using immunohistochemical analysis.The correlation among expression of LAMA4 and age,gender,lesion location,clinical stage,differentiation degree andlymphatic metastasis were analyzed.Results The positive expression rate of LAMA4 in the carcinoma tissue was significantly lower than that in the adjacent tissue [48.5％ (32/66) vs 86.4％ (57/66)] (P ＜0.05).The expression of LAMA4 was correlated with the clinical stage,differentiation degree,lymph node metastasis (x2 =7.984,6.309,4.092,P ＜ 0.05),but it was not correlated with the lesion location,gender and age (P ＞ 0.05).Conclusion In early laryngeal,LAMA4 gene expression is down-regulated,which can inhibit the invasion and metastasis of tumor.