他汀类药物作用机制的研究进展

摘要

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors,referred to as "statins",are the major prescribed medication for hypercholesterolemia and high low density lipoprotein cholesterol,therefore are widely used in primary and secondary prevention of coronary heart disease.Recent studies have found that statins not only possess lipid-lowering effect,but also inhibit vascular inflammation,repair and improve endothelial function,reduce vascular remodeling,promote plaque stabilization in preventing cardiovascular disease;in addition,statins also interfere with a series of lipid intermediates metabolism and protein prenylation.This article reviewed the other activities of statins besides lipid-lowering effect.%他汀类药物为3-羟基-3-甲基戊二酰辅酶A(HMG-COA)还原酶抑制剂,是临床高胆固醇血症和高低密度脂蛋白胆固醇血症的首选药物,广泛应用于冠心病的一、二级预防.近年来研究发现,他汀类药物对心血管疾病的防治不仅仅依赖于其降脂作用,他汀类药物还可抑制血管炎症反应,修复和改善血管内皮功能,减轻血管重塑,稳定斑块等,进而抑制动脉粥样硬化的形成;此外,他汀类药物还干扰一系列脂质中间体的合成代谢及蛋白质的异戊烯化.本文对他汀类药物降脂以外的其他重要生物学作用进行综述.