内皮型一氧化氮合酶Glu298Asp基因多态性与老年原发性高血压微量白蛋白尿的关系

摘要

Objective To investigate the association between endothelial nitric oxide synthase (eNOS)gene Glu298Asp polymorphisms and microalbuminuria(MAU) in elderly patients with essential hypertension(EH). Methods 24-hour microalbuminuria the whole day was quantified in 202 elderly patients with EH,but without dominant proteinuria. and eNOS gene Glu298Asp polymorphisms was assayed by gene chip technology.According to 24-hour microalbuminuria,patients were divided into two groups:microalminuria group(MAUgroup) and normoalbuminuria group(NAUgroup).The allele and genotype frequency distributions were compared between the two groups. Results In the two groups there are different distribution frequencies beteen G allele and T allele.So was among the three genotypes(GG,GT and TT).The frequencies of T allele and the genotypes with T allele in the MAU group were remarkably higher than the NAU group(x2=6.62, P<0.01;x2=7.29, P<0.01).Mutation of T allele caused a high relative ratio risk ratio of MAU in elderly patients with hypertension(OR=2.361,95%CI=1.256~4.437). Conclusion T alllele is one suscepitibity gene of elderly hypertensive patients with MAU.Elderly hypertensive patients carrying T allele are susceptible to MAU..%目的：研究内皮型一氧化氮合酶（eNOS）Glu298Asp基因多态性与老年原发性高血压（EH）微量白蛋白尿（MAU）的关系。方法从到医院就诊的老年EH患者中筛选出202例无显性蛋白尿的患者，行24h MAU测定，并应用基因芯片技术检测eNOS Glu298Asp基因多态性，按照24hMAU定量分为MAU组和非MAU组（NAU组），比较两组基因型和等位基因分布差异。结果两组等位基因和基因型的分布不同，MAU组等位基因T及含等位基因T的基因型（GT+TT）分布频率明显升高（x2=6.62，P＜0.01；x2=7.29，P＜0.01）；T等位基因变异使老年EH患者MAU的相对危险度显著增高（OR=2.361，95%CI=1.256～4.437）。结论T等位基因是老年EH患者MAU的易感基因，携带T等位基因导致老年EH患者出现MAU的风险显著增高。