目的:分析ASC与Caspase-1在淋巴瘤组织及癌旁组织中的表现及与临床的关系.方法:对30例术前未使用放疗与化疗的淋巴瘤组织及其相应的癌旁组织标本采用免疫组化LSAB法进行ASC、Caspase-1测定,并用统计学方法对各指标进行分析.结果:ASC阳性率在肝癌组织及癌旁组织中分别为16.67%(5/30)和76.67%(23/30),组间阳性表达率差异有统计学意义(P<0.01);Caspase-1阳性率分别为26.67%(8/30)和63.33%(19/30),组间阳性表达率差异有统计学意义(P<0.01).ASC与Caspase-1两指标在癌组织中的表达均减少,但差异无统计学意义(P>0.05),在癌旁组织中表达均显著增高(P<0.01).结论:ASC、Caspase-1在淋巴瘤中表达低,且显著低于癌旁组织,提示ASC、Caspase-1与淋巴瘤的凋亡、发生及发展过程密切相关,可成为淋巴瘤的诊断及治疗有希望的靶点.%Objective: To analyze the ASC and Caspase-1 in lymphoma and cancer tissues and the clinical performance and relationships.Methods: 30 patients did not use preoperative radiotherapy and chemotherapy of lymphoma and its corresponding adjacent tissue samples by imrnunohistochemistry LSAB method ASC, Caspase-1 determination, and use statistical methods to analyze the various indexes.Results: ASC-positive rates in hepatocellular carcinoma and adjacent tissues were 16.67％ (5/30) and 76.67％ (23/30) positive rates between the groups were significantly different (P＜0.01); Cas-pase-1-positive rates were 26.67％ (8/30) and 63.33％ (19/30), positive expression rates between the groups were significantly (P＜0.01).ASC and the two indicators of Caspase-1 expression in cancer tissues were reduced, but the difference was not significant (P＞0.05), in adjacent tissue were significantly increased (P＜0.01).Conclusion: ASC, Caspase-1 expression in lymphoma is low, and significantly lower than the adjacent tissues, suggest that ASC, Caspase-1 and apoptosis of lymphoma, the occurrence and development are closely related, which could be the diagnosis and treatment of lymphoma promising targets.
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