目的:评价前列地尔乳剂的安全性.方法:采兔血配制成2%的红细胞混悬液,进行溶血试验;兔耳缘静脉分别注射前列地尔乳剂和生理盐水,观察药物对血管的刺激性;豚鼠腹腔注射前列地尔乳剂,观察过敏反应.结果:前列地尔乳剂对兔红细胞未出现溶血和凝聚作用;家兔耳缘静脉未见明显刺激作用;豚鼠仅出现轻微搔鼻或颤抖反应,未引起死亡.结论:前列地尔乳剂无溶血作用,元血管刺激性,无过敏反应,安全性符合要求.%Objective: To evaluate the safty of Alprostadil Emulsion. Methods: Preparated rabbit blood into 2％ erythrocyte suspension for hemolytic test. In order to observe the stimulation vessel, Alprostadil Emulsion and 0.9％ Sodium chloride injection were injected into ear vein of rabbit respectively. The allergic response on guinea pig in vitro were performed.Results: It was showed that the Alprostadil Emulsion had no hemolysis and agglomeration effects on the red blood cell of rabbit while no significant stimulation on ear vein. Guinea pig only appeared minor response, such as slight scratching nose or shivering response, did not cause death. Conclusion: It is proved that the Alprostadil Emulsion has no hemolyzation, stimulation on blood vessel and allergic reactions. The safety of Alprostadil Emulsion is fit for the requirements.
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