雷公藤多苷对IgA肾病者肾功能、TGF-β1和部分免疫指标的影响效果观察及其探讨

摘要

Objective To observe and explore the influence of Tripterygium Glycosides on the renal function and part TGF-β1 immune parameters of patients with IgA nepharopathy. Methods 42 patients with IgA nephropathy receiving Tripterygium Glycosides treatment were assigned to the experimental group, while 42 patients with IgA nephropathy receiving conventional western medicine treatment were assigned to the control group. The curative effects, liver and kidney function, urinary protein excretion, TGF-pi, CD4+ and CD8+ indicators of the two groups were detected. Then the obtained data was analyzed statistically. Results The total effective rate of the two groups was significantly different (P ＜ 0.05); the 24-hour urinary protein excretion, BUN and Scr levels of the experimental group before and after treatment were significantly different (P ＜ 0.05), while the above renal function indicators and the 24-hour urinary protein excretion of the two groups after medication were significantly different (P ＜ 0.05). The urine TGF-β1/turine Cr and blood TGF-(3, levels of the experimental group before and after treatment were significantly different (P ＜ 0.05), while the above indicators of the two groups of patients after medication were significantly different (P ＜ 0.05). The CD4+ and CD8+ levels of the experimental group before and after medication were significantly different (P ＜ 0.05), while the above indicators of the two groups after medication were significantly different (P ＜ 0.05). Conclusion Tripterygium Glycosides can remarkably improve the urinary TGF-β1/ urinary Cr, blood TGF-β1, and CD4+ and CD8+ levels, and protect the renal function.%目的 对雷公藤多苷对IgA肾病者.肾功能、TGF-β1部分免疫指标的影响效果进行观察与探讨.方法 选取42例给予雷公藤多苷进行治疗的IgA肾病者视为试验组,于同期选取42例给予常规西医治疗的IgA肾病者作为对照组,同时对两组患者治疗效果、肝肾功能、尿蛋白定量和TGF-β1和CD4+,CD8+指标实施检测,然后对所得数据进行统计学分析.结果 两组患者总有效率相比,差异有统计学意义(P<0.05),试验组患者治疗前后24 h尿蛋白定量、尿素氮(BUN)、血肌酐(Scr)水平相比,差异有统计学意义(P<0.05),而给药后两组患者上述肾功能指标、24 h尿蛋白定量相比,差异有统计学意义(P<0.05);试验组患者给药前后尿TGF-β1/尿肌酐(Cr)、血TGF-β1水平相比,差异有统计学意义(P<0.05),而给药后两组患者上述指标相比,差异有统计学意义(P<0.05);试验组患者给药前后CD4+,CD8+水平相比,差异有统计学意义(P<0.05),而给药后两组患者上述指标相比,差异有统计学意义(P<0.05).结论 雷公藤多苷能够明显改善尿TGF-β1/尿Cr、血TGF-β1以及CD4+,CD8+水平,保护肾功能.