缺血性脑血管病患者颈动脉粥样硬化程度与血浆神经肽Y 水平的相关性分析

摘要

目的 分析缺血性脑血管病患者颈动脉粥样硬化程度与血浆神经肽Y(NPY)水平的相关性.方法 采用放射免疫法检测缺血性脑血管病患者[包括急性脑梗死、短暂性脑缺血发作(TIA)和颈动脉粥样硬化患者]和健康体检者(对照组)血浆NPY 水平;采用彩色多普勒超声检测缺血性脑血管病患者颈动脉内膜中层厚度(IMT).结果 缺血性脑血管病患者NPY 水平较对照组明显升高(P < 0.01);随着颈动脉粥样硬化程度加重,血浆NPY 水平呈现增高趋势;颈动脉重度狭窄患者NPY 水平与轻、中度狭窄患者相比差异有统计学意义(P < 0.05);急性脑梗死和TIA 患者较单纯颈动脉粥样硬化患者血浆NPY 明显升高(P < 0.05).缺血性脑血管病患者中血浆NPY 水平与IMT 值呈正相关关系(r = 0.163、0.245、0.179,P < 0.05).结论 NPY 可反映颈动脉粥样硬化的程度且参与颈动脉粥样硬化的病理生理过程.%Objective To analyze the correlation between the level of blood plasma neuropeptide Y (NPY) and carotid atheroscle -rosis degree in patients with ischemic cerebrovascular disease. Methods The blood plasma NPY level of patients with is chemic cerebrovascular disease [patients with acute cerebral infarction, transient ischemia attach (TIA) and carotid atheroscle -rosis were include] and health people (control group) was measured by radioimmunity. The intima-medium thickness (IMT) of carotid artery in patients with ischemic cerebrovascular disease was detected by colour Doppler ultrasonography. Results Compared with control group, the blood plasma NPY level of ischemic cerebrovascular disease patients increased signifi -cantly (P < 0.01). Accompany with the aggravation of carotid artery stenosis, the level of blood plasma NPY appeared an increase trend. In comparison with light and middle degree of carotid artery stenosis, the blood plasma NPY level of patients with serious carotid artery stenosis increased significantly (P < 0.05). Compared with single carotid atherosclerosis patients, the blood plasma NPY level of TIA patients and acute cerebral infarction patients increased significantly (P < 0.01). Among patients with ischemic cerebrovascular disease, the blood plasma NPY level had a positive correlation with IMT (r = 0.163, 0.245, 0.179, P < 0.05). Conclusion NPY can indicate the degree of carotid artery stenosis and also participates in the pahtophysiologic process of arotid artery stenosis.