心肌肌钙蛋白Ⅰ水平在慢性心力衰竭患者中检测的价值分析

摘要

Objective To investigate clinical value of cardiac troponin I (cTnl) levels in patients with chronic heart failure. Methods CTnl levels of 114 patients with chronic heart failure were checked. The correlation among cTnl and cardiac function, left ventricular ejection fraction and cardiac structure were analyzed. Results The cardiac function class IV in patients with CHF cTnl levels were significantly higher than class Ⅲ and class II patients (t = 13.23, 9.62, P < 0.01), class IH patients' cTnl level were significantly higher than that of class II patients (t = 7.54, P < 0.01), and LVEF<40% patients' cTnl levels were significantly higher than that of LVEF 40%-50%, LVEF>50% patients (t= 18.34, 13.86, P < 0.01). LAD and LVEDd in CTnl elevated group were significantly higher than those of the normal group (t = 6.54, 7.45, P < 0.01), and LVS, LVPW in normal group was significantly higher than elevated group, the difference was statistically significant (t = 16.54, 8.78, P < 0.01). Conclusion cTnl level can reflect cardiac function in patients with CHF, left ventricular ejection conditions and ventricular remodeling situation. It's worthy of promotion and application.%目的 探讨心肌肌钙蛋白I(cTnI)水平在慢性心力衰竭患者中检测的临床价值.方法 对114例慢性心力衰竭(CHF)患者cTnI 水平进行检查,并分析cTnI 与心功能分级、左室射血分数以心脏结构的关系.结果 心功能Ⅳ级的CHF 患者cTnI 水平明显高于心功能Ⅲ级和心功能Ⅱ级患者的cTnI 水平(t = 13.23,9.62,P < 0.01),心功能Ⅲ级患者的cTnI 水平明显高于心功能Ⅱ级患者的cTnI 水平(t = 7.54,P < 0.01),并且LVEF<40%的患者cTnI 水平明显高于LVEF 40%～50%、LVEF>50%患者cTnI 水平,差异有高度统计学意义(t = 18.34,13.86,P < 0.01),LAD 和LVEDd 在CTnI 升高组患者中明显高于CTnI 正常组患者(t = 6.54,7.45,P < 0.01),而LVS、LVPW 在CTnI 正常组中显著高于CTnI 升高组,差异有高度统计学意义(t = 16.54,8.78,P < 0.01).结论 CTnI 能够反映CHF 患者心功能分级、左室射血及心室重构情况,值得临床推广应用.