射频消融术联合化疗与手术联合化疗治疗声门型喉癌的效果对比

摘要

Objective To compare clinical efficacy of radiofrequency ablation combined with chemotherapy and surgery combined with chemotherapy in the treatment of glottic carcinoma. Methods Totally 92 patients with glottic carcinoma in Shaanxi General Hospital of CAPF from December 2013 to December 2014 were randomly divided into observation group and control group by simple random method, with 46 cases in each group. Control group was treated by surgery combined with chemotherapy, while observation group was treated by radiofrequency ablation combined with chemotherapy. Clinical efficacy, KPS scores, the incidence of adverse reaction, apoptosis rate, recurrence rate and the survival rate of patients in the two groups were compared. Results After the treatment, clinical efficacy of patients in the observation group after treatment was significantly higher than that in the control group, the difference was statisti-cally significant (P< 0.05). KPS scores of patients in observation group after treatment was significantly higher than that of the control group, the difference was statistically significant (P<0.05). The incidence of level 3 and 4 adverse reaction of patients in observation group after treatment was significantly lower than that of the control group, the dif-ference was statistically significant (P< 0.05). The apoptosis rate of patients in observation group after treatment was significantly higher than that in control group, the difference was statistically significant (P<0.05). The recurrence rate and the survival rate were no significant difference between two groups (P> 0.05). Conclusion Radiofrequency abla-tion combined with chemotherapy in treatment of glottic carcinoma can enhance clinical efficacy, life quality and the apoptosis rate, and reduce the incidence of adverse reaction. It is worthy of clinical application.%目的：比较射频消融术（RFA）联合化疗与手术联合化疗治疗声门型喉癌的临床效果。方法选择2013年12月~2014年12月武警陕西总队医院收治的声门型喉癌患者92例，采用简单随机法将患者分为对照组与观察组，每组各46例。对照组患者给予手术联合化疗治疗，观察组患者给予RFA联合化疗。对治疗后两组患者的临床疗效、生活质量KPS评分、不良反应发生率、肿瘤细胞凋亡率、术后复发情况及存活率进行比较。结果治疗后，观察组临床治疗有效率及临床症状控制率均高于对照组，两组比较差异有统计学意义（P<0.05）；观察组患者的生活质量KPS评分明显高于治疗前和对照组，差异有统计学意义（P<0.05）；观察组Ⅲ级及Ⅳ级不良反应的发生率均低于对照组，两组比较差异有统计学意义（P<0.05）；观察组肿瘤细胞凋亡率高于对照组，两组比较差异有统计学意义（P<0.05）。两组复发率及存活率比较，差异均无统计学意义（P>0.05）。结论对声门型喉癌患者进行RFA联合化疗治疗，可明显提高临床疗效、生活质量及肿瘤细胞凋亡率，减少不良反应，值得临床推广与应用。