Objective:To observe the effects of Chinese herb of promoting blood circulation to dissipate blood stasis on the levels of tumor necrosis factor alpha(TNF-a)and interleukin 6(IL-6) in serum of patients with mudslide injuries,and investigate the mechanisms of Chinese herb of promoting blood circulation to dissipate blood stasis in the treatment of mudslide injuries. Methods: Patients with mudslide injuries who were translated from Zhouqu and Chengxian to Lanzhou from 12th August 2010 were divided into two groups (group A and group B). Twenty-five patients in group A,containing 15 males and 10 females,with an average age of (39.0±3.9) years. According to AIS scoring system, 1 point in 2 cases,2 points in 3,3 points in 17 and 4 points in 3. No patients got 5 points. Based on ISS rating system, 16 cases got 16 points or less,7 cases rated between 16 and 25,only 2 cases were equal to 25 points or more. Another 25 patients were in group B,including 11 males and 14 females,with a mean age of(40.1±3.6) years;AIS score showed 3 cases got 1 point,4 got 2 points, 16 got 3 and 2 got 4 points.no patients got 5 points. Patients in group B were divided into three parts by ISS score: 15 cases (16 points or less) ;9 cases (range 16 to 25 points) and 1 case(25 points or more). All the patients accepted general physical checkup. Eight patients were treated by surgical treatment in group A (3 patients were treated with open reduction plate fixation,4 patients were treated with de-bridement BHID.and 1 patient underwent foreign body removal) and 6 cases in group B( 1 patient was treated with craniocere-bral surgery,2 patients were treated with chest surgery,and 3 patients were treated with soft tissue debridement). All the patients of two groups were treated by support treatment, detumescence treatment and preventing infection, complications. A seven days course of treatment with detumescence analgesic mixture 50 ml p.o. Bid, traumatologic cleansing liquid 20 ml ad us, ext 20 to 30 min qid to group A .continuous treatment of two courses. Using immunometric assay to determine serum levels of inflammatory cytokine TNF-α,IL-6 at the 2nd,7th, 14th days after admission. Analysis of data were done with the help of SPSS 16.0 statistic software. Results:There were no statistical differences of TNF-a,IL-6 between two groups at the second day after admission,and there were statistical differences at the /th and 14th days between two groups. I here were significant dinerences of TNF-a and IL-6 levels between the 7th day and the 2nd day,the 14th day and 2nd day after admission. Conclusion:The Chinese herb of promoting blood circulation to dissipate blood stasis can inhibit the release of inflammatory factor aftertraumatism.%目的:观察活血化瘀中药对泥石流损伤患者血清肿瘤坏死因子-α、白细胞介素-6的影响,探讨活血化瘀中药在灾害救治中的作用机制.方法:以2010年8月12日起由甘肃舟曲和成县转运至兰州的泥石流伤员为研究对象,分为2组.A组25例,男15例,女10例;平均年龄(39.0±3.9)岁;AIS评分1分2例,2分3例,3分17例,4分3例,无5分患者;ISS评分＜16分16例,1625分7例,>25分2例.B组25例,男11例,女14例;平均年龄(40.1±3.6)岁;AIS评分1分3例,2分4例,3分16例,4分2例,无5分患者;ISS评分＜16分15例,16～25分9例,>25分1例.2组患者入院后完善全身检查,A组8例手术治疗,其中3例行切开复位钢板内固定术,4例行扩创引流术,1例行异物取除术;B组6例手术治疗,其中颅脑手术1例,胸部手术2例,软组织清创术3例.2组患者均常规预防感染、预防并发症、支持及消肿治疗,A组在此基础上另内服消肿止痛合剂,每次50 ml,每日2次;外用伤科洁肤液外敷患部,每次20 ml,每日4次,每次外敷20～30 min.2组患者均以7d为1个疗程,共治疗2个疗程,分别于入院第2、7、14天运用免疫度量法测定促炎症细胞因子TNF-α、IL-6于血清中的含量,所测TNF-α、IL-6不同时间点的数据采用SPSS16.0统计学软件进行处理.结果:入院第2天,2组患者血清TNF-α、IL-6的含量比较,差异无统计学意义;第7、14天2组血清TNF-α、IL-6的含量比较,差异有统计学意义.入院第7、14天与入院第2天血清TNF-α、IL-6含量比较,差异有统计学意义.结论:活血化瘀中药能抑制创伤后致炎症因子释放.
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