血清中亚甲基四氢叶酸还原酶活性与白癜风临床特征相关性研究

摘要

Objective:To determine the correlation between the serum methylenetetrahydrofolate reductase (MTHFR) activity and clinical features of the patients with vitiligo.Methods:The MTHFR activity was detected by enzyme-linked immunosorbent assay (ELISA) in 90 patients with vitiligo and 90 controls with matched age and sex.Results:The mean level of MTHFR was 332.77±92.85 U/L in vitiligo, which was lower than that in controls (403.66±96.56 U/L), (P<0.0001).The level of MTHFR activity in stable vitiligo, progressive vitiligo and rapid progressive vitiligo was decreased in a descending manner.There was no significant difference of MTHFR activity in sex, family history and duration of the disease.Conclusion:Reduction of MTHFR activity may be associated with the development of vitiligo.%目的:明确白癜风患者血清中亚甲基四氢叶酸还原酶(MTHFR)活性与白癜风临床特征间的关系.方法:选择性别年龄相匹配的白癜风患者及健康对照各90例,采用ELISA法检测血清中MTHFR活性.结果:白癜风患者血清中MTHFR活性为(332.77±92.85)U/L,显著低于对照组的(403.66±96.56)U/L,(P<0.0001).静止期、进展期及快速进展期患者血清中MTHFR活性呈逐级降低趋势.MTHFR活性在患者性别、家族史、病程等方面无显著差异.结论:白癜风患者血清中MTHFR活性降低可能与白癜风疾病发展相关.