Preparation and Preliminary Biological Evaluation of c-Gluc-Lys(Al18FNOTA)-TOCA

摘要

18F labeled somatostatin analogues that bind to the somatostatin receptors(SSTR)on some tumor cells with high specific affinity hold great potential for diagnostic imaging.After glycosylationmodification,the pharmacokinetic properties of somatostatin analogues were significantly optimized,the hepatobiliary uptakes were reduced,and tumor-targeting were improved.In order to explore a novel PET