Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy

摘要

Metal-organic frameworks(MOFs)have recently allured a variety of concern in the fields of nanotechnology.However,exploring their biomedical applications is still a relatively new field.In this work,zeolite imidazole skeleton-8(ZIF-8)was reported for the first time as a drug carrier for the treatment of lung injury.Uniform ZIF-8 nanoparticles encapsulating plumbagin(PLB)are achieved by a facile physical adsorption process.Scanning electron microscopy(SEM),powder X-ray diffraction(PXRD)and UV–vis absorption spectrum were conducted to investigate the physical properties of ZIF-8 and PLB@ZIF-8.In animal model,the collagen fibers deposition produced by severe lung injury is significantly decreased.The secretion of inflammatory factor TGF-βand IL-6 were efficiently dropped by the combination of plumbagin and ZIF-8.At the same time,the expressions of collagen I,α-SMA and TNF-αwere also suppressed.This strategy puts forth a promising blueprint in the application of MOF materials,especially in biomedical fields.