Catalyst-free,direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF_(3) source

摘要

A new electrochemical strategy for trifluoromethylation/cyclization using TfNHNHBoc as a CF_(3)source was established.This approach was realized by the direct electrolysis of Tf NHNHBoc under external oxidantfree and catalyst-free conditions,and afforded various trifluoromethylated oxindoles with good functional group compatibility and broad substrate scope.Preliminary mechanistic studies show that the reaction proceeds by a radical process.