猪杀菌性/通透性增强蛋白（BPI）的功能及其在抗病育种中应用的研究进展

摘要

杀菌性/通透性增强蛋白(bactericidal/permeability-increasing protein,BPI)有较强的杀菌作用(主要为革兰氏阴性菌)和中和脂多糖(lipopolysaccharide,LPS)的活性,以及增强单核细胞和嗜中性粒细胞对病原菌的吞噬功能。近年来,BPI 的生物学功能受到广泛关注,被称为机体内的“超级抗生素”,BP I 基因被很多学者作为抗病候选基因进行探索。作者综述了猪 BP I 基因的结构、生物学功能及其与猪抗性的关系等,阐述了 BP I 基因在猪抗病育种中的研究进展及应用前景,为下一步猪 BP I 基因的功能研究及其在抗病育种实践中的应用提供理论依据。%Bactericidal/permeability-increasing protein (BPI)has a strong effect on sterilization (mainly for G- bacteria),neutralizing the activity of lipopolysaccharide (LPS)and enhancing the phagocytosis of mononuclear cells and neutrophils to pathogenic bacteria.The biological functions of BPI have been researched widely in recent years,which is known as “super antibiotic”and has been explored by many scholars as a candidate gene for resistance.This author summarized the re-search progress and application prospect of the BP I gene in the pig resistant breeding by introdu-cing the structure,biological function of BP I gene and its relationship with the resistance,which was aimed to provide theoretical references and basis for the function research of pig BP I gene and its practical application in resistance breeding in future.