1-芳基亚甲基-2-（6-（3,5-二甲基-1H-吡唑-1-基）-1,2,4,5-四嗪-3-基）肼的合成及抗菌活性

摘要

The titled compounds（5） were synthesized by the hydrazone reaction of aromatic aldehydes and 3-（3,5-dimethyl-1H-pyrazol-1-yl）-6-hydrazinyl-1,2,4,5-tetrazine（4） prepared from hydrazine hydrate and guanidine nitrate via cyclization,oxidation and hydrazine reaction.They had been identified by elemental analysis,1H NMR,IR and MS.The results of preliminary bioassays showed that parts of as-synthesized compounds（5） exhibit moderate inhibitory activity to E.coli.,S.aureus and B.subtilis.%以水合肼和硝酸胍为原料,经过环合、氧化和肼化,得到3-（3,5-二甲基-1H-吡唑-1-基）-6-肼基-1,2,4,5-四嗪（4）,以此为原料和不同芳香醛发生腙化反应,得到系列1-芳基亚甲基-2-（6-（3,5-二甲基-1H-吡唑-1-基）-1,2,4,5-四嗪-3-基）肼（5）,产物经元素分析、1H NMR、IR和MS表征。所合成的系列化合物抗菌活性测试表明,它们对大肠杆菌、金黄色葡萄球菌、枯草杆菌等3种细菌表现出一定程度的抑制活性。