PEG-400介质中L-脯氨酸催化香豆素-3-羧酸乙酯的合成

摘要

L-proline could effectively catalyze the synthesis of ethyl coumarin-3-carboxylate from aldehydes and diethyl malonate u-sing PEG-400 as the solvent This method had the advantages such as easy to operate,convenient work-up,short reaction time,high reaction yield,cheap catalyst and solvent,and environmentally benign procedure.%用PEG-400为溶剂,L-脯氨酸作为催化剂,能高效简便地催化水杨醛与丙二酸二乙酯通过Knoevenagel缩合反应得到香豆素3-羧酸乙酯.本方法具有易于操作,后处理方便,反应时间较短,反应收率较高,催化剂和溶剂价廉易得,而且环境友好等优点.