@@ 相对于正电子发射成像(PET)、计算机断面成像(CT)、单光子发射计算机断面成像(SPECT)以及核磁共振成像(MRI)等成像模式而言,光学成像具有无辐射、低成本的特点,尤其是近红外荧光成像可以部分实现对深层组织和器官的探测和成像,在分子成像方面具有特定的优势[1～4].分子影像的核心是分子探针,主要面临的问题包括深层次光的传输和采集以及分子探针的发光量子效率、良好的生物相容性和靶向性[5,6].针对在体光学成像对分子探针的基本要求设计具有强近红外荧光发光特性、对恶性肿瘤具有高特异性结合和高灵敏度的分子探针体系,对于提高近红外光学分子成像至关重要[6～8].含四吡咯基团的近红外荧光染料(如酞菁)是近年来关注的焦点,因具有良好的光物理行为使其在近红外探针方面具有较好的应用前景[9,10].在分子探针设计中,靶向性是一个关键问题.%Near-infrared fluorescence imaging can be used in deep tissues and organs for detecting and imaging in biological tissue. It provides effective methods of tumor detecting and tracking the diseases treatments.In order to develop tumor special probe and improve diagnose effect, phthalocyanine conjugation with galaetose was synthesized as near-infrared fluorescent probes. The probe had good water-solubility and high emission ability in near-infrared region. In vivo fluorescence imaging effect and organ distribution of probe were conducted with nude mice bearing liver cancer as model. The results show that galactose modified phthalocyanine has obvious near-infrared imaging effect in vivo and a certain tumor targeting ability. So the near-infrared optical probe can be potentially applied in the diagnosis of cancer in future.
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