Celiac disease is a multisystemic dietary,gluten-induced autoimmune disorder characterized by the presence of transglutaminase(TG)2 serum autoantibodies.Distinct autoantibodies targeting members of the TG family(TG2,TG3 and TG6)are found deposited in small-bowel mucosa and in extraintestinal tissues affected by the disease.Serum autoantibodies against other self-antigens also emerge in untreated celiac disease patients.Although villous atrophy and crypt hyperplasia in small-bowel biopsy samples are still the gold standards in diagnostics,celiac disease-specific antibodies are widely used as diagnostic aids.Gluten-induced small-bowel mucosal T-cell response is the cornerstone in the pathogenesis of the disorder,but humoral immunity may also play a central role.This review article is focused on the autoantibodies that occur in the context of celiac disease.The article summarizes the diagnostic utility of different celiac-related antibodies and discusses their roles in the pathogenesis of the disease.
展开▼
