The aryl hydrocarbon receptor and the gut–brain axis

摘要

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for dioxin.Almost half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and disease.In this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.