Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors

摘要

Dear Editor,Parkinson's disease (PD) is a neurodegenerative disease that afflicts around 1％ of the population over age 65 [1].One of the pathological hallmarks of PD is the degeneration of dopaminergic (DA) neurons at midbrain and the relatively focal lesion feature of PD makes cell replacement a promising approach for treating the disease [2].