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首页> 外文期刊>癌症生物学与医学：英文版 >Aldehyde dehydrogenase 2 suppresses cirrhosis and alcohol-induced hepatocellular carcinoma via the inhibition of acetaldehyde-derived DNA damage and multiple oncogenic signaling pathways
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Aldehyde dehydrogenase 2 suppresses cirrhosis and alcohol-induced hepatocellular carcinoma via the inhibition of acetaldehyde-derived DNA damage and multiple oncogenic signaling pathways

机译：乙醛脱氢酶2通过抑制乙醛衍生的DNA损伤和多种致癌信号通路来抑制肝硬化和酒精诱导的肝细胞癌

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Objective:Hepatocellular carcinoma(HCC)is the most common primary liver cancer,the fifth most common cancer and the third most common global cause of cancer related deaths.Chronic alcohol consumption is a well-known risk factor for HCC.Acetaldehyde,a main metabolite of ethanol oxidation.
机译：Objective:Hepatocellular carcinoma(HCC)is the most common primary liver cancer,the fifth most common cancer and the third most common global cause of cancer related deaths.Chronic alcohol consumption is a well-known risk factor for HCC.Acetaldehyde,a main metabolite of ethanol oxidation,is a very reactive compound involved in alcoholinduced liver damage.Aldehyde dehydrogenase 2(ALDH2)is a key enzyme to detoxify produced acetaldehyde and it has a protective role against acetaldehyde-derived DNA damage in esophageal cancer.However,the effects of ALDH2 in the progression of HCC and the underlying mechanisms remain largely unknown.

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