BMP1基因在动物卵泡发生和胚胎发育中的表达规律及调控机制的研究进展

摘要

骨形态发生蛋白1（BMP1）是一类属于虾红素家族的金属蛋白酶，它在细胞外基质的形成以及调控TGFβ信号通路的过程中发挥重要作用。BMP1基因在动物卵泡发育过程中具有不同程度表达，并以某种形式参与了动物胚胎的发生和发育过程。开展对BMP1基因的研究将有助于人们从基因角度进一步阐明动物卵泡的形成和胚胎发育的机制，对医学和畜牧业等领域将产生积极的影响。着重从BMP1基因在动物胚胎发育过程中的表达定位、功能及其机制进行综述。%Bone morphogenetic protein 1(BMP1)is a kind of metalloproteinases belongs to the astacin family, its play an important role in the process of the formation of extracellular matrix and regulating TGFβsignaling pathways. BMP1 gene expressed in the follicular development with different expression levels, and involved in the embryogenesis and development of animal embryos in some way. The research on BMP1 gene may help people from genetic point of view to clarify the mechanisms of the formation follicular and embryo development, and then may have a positive impact on animal husbandry and other fields of medicine. This review will focus on BMP1 gene expression in the process of animal embryonic development orientation, function and its mechanism involved.