Effect of Smo SiRNA-mediated Hedgehog Signaling Pathway Inhibition on Palatal Fusion

摘要

We used Smo siRNA to inhibit hedgehog signaling pathway in embryonic day(E)13 palatal shelves in organ culture.Si RNA 4 was chosen as the most efficient from four synthesized Smo si RNAs.Palatal shelf fusion rate of 4μg/m L cyclopamine group was the lowest and significantly lower than that of blank control group(P<0.05),and that of si RNA 4 group was also lower than that of