啶虫脒/木质素两性表面活性剂/膨润土缓释剂的制备及性能

摘要

以木质素两性表面活性剂二甲基-正丁基-磺化木质素基氯化铵( DBSLAC)为改性剂,钠基膨润土为原料,制备了DBSLAC改性膨润土( L-Bt)。以啶虫脒为药物释放的对象、改性膨润土作为释放的主要载体,利用浸渍负载的方法制备了啶虫脒缓释剂,对制备条件进行了优化,并研究其缓释性能。通过FT-IR表征了样品结构,采用XRD分析了晶体层间距。结果表明：DBSLAC已成功插入膨润土层间,使其层间距增大。啶虫脒缓释剂制备最佳工艺条件为改性膨润土为L-1.2Bt、投加量0.02 g、负载时间6 h、啶虫脒初始质量浓度500 mg/L、溶液 pH 值6,制得的缓释剂的最大负载量为333 mg/g。通过水溶缓释实验探究了药水比例和温度对载药L-1.2Bt的累积释药率的影响,结果表明,累计释药率随水的比例的增加、温度的升高而逐渐上升,最后趋于稳定。%Lignin based amphoteric surfactant ( dimethyl-butyl-sulfonated lignin ammonium chloride, DBSLAC ) was used as modification agent to exchange the metal ions among the layers of sodium-based bentonite to prepare modified bentonite( L-Bt) . Acetaniprid was selected as the drug for slow-release and loaded on the modified bentonite by means of adsorption, and the slow-release performance was studied. The structure and basal spacing of modified bentonite were analyzed with by FT-IR and XRD. The results showed that the DBSLAC inserted the interlayer of modified bentonite successfully which caused the increase of interlayer distance. The optimum adsorption conditions for acetaniprid slow-release formulation were modified bentonite L-1. 2Bt, dosage 0. 02 g, adsorption time 6 h, initial mass concentration of acetaniprid 500 mg/L and pH value 6. Under these conditions the maximum loading capacity was 333 mg/g. The effects of potion proportion and temperature on the accumulative release rate of L-1. 2Bt were studied by water soluble method. With the increase of water content and temperature, the accumulative release rate increased gradually, and finally tended to be stable.