USP22在肿瘤发生发展中的作用研究进展

摘要

USP22 is the ubiquitin-specific peptidase and a subunit of hSAGA complex subunit, belonging to the DUBs. Within hSAGA, USP22 deubiquitylates histone H2A and H2B and acetyltra-nsfers H4 to regulate the transcription and expression of the related genes. Now that it is believed that USP22 is one of the death-from-cancer signature and associated with proliferation, invasion, metastasis and poor prognosis. It promotes the occurrence and development of tumor corresponding with the BMI-1,which is one of the Polycomb group like MYC,FBP1 ,TRF1. That makes it possible to become one of the tumor stem cell marker.%USP22是一种泛素特异肽酶,属于DUBs家族,是hSAGA复合物的一个亚单位,参与组蛋白去泛素化、乙酰化进而参与hSAGA复合物所调节的基因转录与表达等.目前认为USP22是癌死亡标签之一,并且它与癌的增殖、侵袭转移和治疗预后相关.USP22与肿瘤发生发展的机制主要与Polycomb家族成员之一BMI-1和MYC、FBP1、TRF1等多种因子有关,这一特点使其可能成为肿瘤干细胞标志物之一.