长链非编码RNA与病毒和微小非编码RNA关系的研究进展

摘要

非编码RNA,包括以miRNA、siRNA和piRNA等为代表的短小RNA和长链非编码RNA.长链非编码RNA,有别于其他小分子非编码RNA,是目前非编码RNA研究的热点.随着研究的不断推进,人们发现lncRNA与物种进化、胚胎发育、物质代谢以及肿瘤发生等都有着密切的联系.microRNA是一类长度为19～ 23个核苷酸的内源性非编码RNA,可以在转录水平或转录后水平调节基因的表达.%Noncoding RNA,including miRNA,siRNA and piRNA as the representative of the short RNA and long chain non coding RNA.long non-coding RNAs (lncRNAs) are hot spots which are different from other smaller noncoding RNAs.lncRNAs have been found to affect species evolution,embryonic development,metabolism and tumorigenesis.MicroRNAs (miRNAs) is a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation.