Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research the First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou Hainan 570102 China;
Hainan Provincial Clinical Research Center for Thalassemia the First Affiliated Hospital of Hainan Medical University Haikou Hainan 570102 China;
Prenatal Diagnosis Center the First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou Hainan 570102 China;
Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical University Haikou Hainan 571199 China;
Texas Heart Institute 6770 Bertner Avenue MC 2-255 Houston TX 77030 USA;