Effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role

摘要

Objective:To observe the effect ofYiqiJianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role.Methods:Human intestinal cancer cellHT29 xenograft of nude mice model was established.The expression ofEGF,VEGF, gastric cancer tumor growth in mice were observed.Results:Protein kinaseC expression in in theYiqiJianpi group andYiqi Jianpi anti-tumor group was significantly better than the model group(P<0.01,P<0.05).There was significantly more apoptotic cells inYiqiJianpi anti-tumor group thanYiqiJianpi group and model group(P<0.01).Epidermal growth factor and vascular endothelial growth factor expression inYiqiJianpi group was significantly lower thanYiqiJianpi group and model group(P<0.05). Conclusions:Tumor can inhibit the expression ofPKC inhibition.YiqiJianpi and anticancer treatment can reduce this inhibition.Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.