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《近代物理研究所和兰州重离子加速器实验室年报:英文版》
>4-67 miR-300 Modulates the Cellular Radiosensitivity Through Targeting p^53 in Human Non-small Cell Lung Cancer A549 Cells
4-67 miR-300 Modulates the Cellular Radiosensitivity Through Targeting p^53 in Human Non-small Cell Lung Cancer A549 Cells
microRNAs(miRNAs)perform crucial roles in mediation of the cellular radiosensitivity by influencing DNA damage repair,cell cycle checkpoint,apoptosis,radio-related signal transduction pathway and microenvironment[1-3].Our previous study have suggested that miR??300,whose expression is correlated positively with the cellular resistance to chemotherapy drug cis-platin in human ovarian cancer cells[4],is involved in the cellular response to the DNA damages induced by ionizing radiation[5].However,the underlying molecular mechanisms remain unclear.
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