Suspected cases of pregnancy toxaemia of Small-tail Han Sheep in a scaled sheep farm in south Xinjiang were diagnosed and analysis by epidemiological investigation, clinical diagnosis method, pathological observation and laboratory examination. The histopathologic changes of the diseased sheep were as followed:the liver enlarged and its section was valgus and greasy, the myocardial cells degenerated and the heart became brittle, the bleeding points were observed in endocardium and epicardium, indicating the typical clinical symptoms of pregnancy toxaemia. The serum content of ALT, AST, ALP and ALB of the diseased sheep was significantly higher than those of the healthy sheep in the same farm (P<0.05), and was also obviously higher than the normal reference range of the healthy sheep. The combined diagnosis results demonstrated that the emerged disease in Small-tail Han Sheep in the sheep farm was pregnancy toxaemia.%采用流行病学调查、临床诊断、病理学观察、实验室检查等方法，对新疆南疆某规模羊场妊娠末期小尾寒羊发生的疑似妊娠毒血症进行诊断及病情分析。结果表明，发病死亡羊只肝脏肿大，切面外翻且油腻，心脏变性、质脆，心内、外膜有出血点，表现出典型的妊娠毒血症临床症状；发病羊只的血清ALT、AST、ALP、ALB含量显著高于健康母羊（P<0.05），且明显高于健康绵羊血清的正常参考值范围。综合上述诊断结果，可以判定该羊场小尾寒羊母羊发生的疾病为妊娠毒血症。
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