苦参、山豆根植物中主要生物碱药学研究进展

摘要

该文综述了药用植物苦参、山豆根主要生物碱分离纯化及含量测定研究进展.对近年来国内外发表的相关文献进行收集、分析整理及归纳.现有文献多为苦参总碱的纯化,而涉及单体生物碱的分离较少;在含量测定方面多以苦参碱、氧化苦参碱等为质控指标,不尽合理.应加强对苦参、山豆根中生物碱的结构多样性、毒理及构效关系等研究,以扩大这类植物活性成分的开发利用,确保临床用药安全可靠有效.%Many extracted purification and determination methods of main alkaloids in S.flavescens and S. tonkinensis medical plants have been summarized. The relevant articles published in recent years were collected , analyzed , arranged and concluded. The existing literature are mostly purification of total Sophora alkaloids. however, the separation of monomer alkaloids are less. The determination of matrine , oxymatrine as quality control indicators is not reasonable in S.flavescens and S. tonkinensis plants. The structure diversity , toxicology and structure-activity relationship of those alkaloids should be strengthened in order to utilize resources and ensure safety and validity of clinical using for S.flavescens and S. tonkinensis plants.