Aim To evaluate different methods of determining levamisole hydrochloride tablets contained in different countries Pharmacopoeia. Methods Reproduction experiment and recovery experiments focused on examining non-aqueous titration method in" Chinese Pharmacopoeia" and"Indian Pharmacopoeia" and HPLC gradient elution method the"United States Pharmacopoeia". Results As for the Chinese Pharmacopoeia method , recovery was 100. 09％ ( RSD = 3. 66％ ) . While for the Indian Pharmacopoeia method recovery was 96. 13％ ( RSD = 0. 86％ ) ,and as for the United States Pharmacopoeia method recovery was 99. 67％ ( RSD = 0. 43％ ). Conclusion High-performance liquid method in " The United States Pharmacopoeia" is stable and reliable. The Indian Pharmacopoeia method. for extracting repeatedly ,leads to low recovery rate. Chinese Pharmacopoeia method is vulnerable to interference because of fewer samples.%目的 筛选比较各国药典中盐酸左旋咪唑片含量测定方法的优异.方法 利用重现实验和回收实验重点考查<中国药典>和<印度药典>所采用的高氯酸非水滴定方法和<美国药典>采用的高效液相梯度洗脱方法.结果 <中国药典>方法回收率为100.09%(RSD=3.66%);<印度药典>方法回收率为96.13%(RSD=0.86%);<美国药典>方法回收率为99.67%(RSD=0.43%).结论 <美国药典>收录的高效液相方法稳定而可靠,<印度药典>收录的方法因多次反复提取,回收率偏低,<中国药典>收录的方法因取样量偏少,实验易受干扰.
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