目的 考察甘露醇注射液与呋塞米注射液、地塞米松注射液和甲泼尼龙琥珀酸钠注射液配伍的稳定性,供临床用药参考.方法 模拟临床常用浓度和配制方法,对配伍后甘露醇注射液与呋塞米注射液、地塞米松注射液和甲泼尼龙琥珀酸钠注射液的外观、pH值及含量指标进行观察研究.结果 呋塞米注射液与甘露醇注射液配液pH值超过甘露醇注射液药典规定限度(4.5～6.5);甲泼尼龙琥珀酸钠注射液与甘露醇配液在低于室温情况下易出现结晶;其他考察项目未发现明显变化.结论 临床中,甘露醇注射液与呋塞米注射液合用可采取与甘露醇注射液交替使用,不仅从理化性质还是临床疗效上均有意义;甲泼尼龙琥珀酸钠注射液应严格控制配液与输注时的环境温度,最好临用前现配或入壶使用.在地塞米松注射液与甘露醇注射液配伍的稳定性考察项目中未发现明显变化,配液后摇匀仔细观察,在未出现结晶的情况下可放心使用.%Objective To inspect the compatibility stability between mannitol injection and three popular auxiliary drop pressure cranial injections. Methods Test was taken under the conditions of room temperature and natural daylight within 6 hours after the compatibility of both mannitol injection and three popular auxiliary drop pressure cranial injections. Meanwhile, the liquid s exterior appreance,pH value as well as the change of the content change were being observed. Results Furosemide and mannitol injection mixed, pH value had been more than mannitol injection pharmacopoeia provided limit( 4. 5 ～ 6. 5 ); Methylprednisolone and mannitol injection appeared more crystallization below room temperature, Other investigation project was not found to change. Conclusion In clinics, mannitol and furosemide injection can be used alternatively. Not only the physical and chemical properties but clinical curative effect all have significant meaning. Methylprednisolone injection and infusion liquid should be strictly controlled with the environment temperature. The best way is to match before using or put it into the pot. No change has been found in Dex amethasone injection and mannitol injection. If there is no crystallization after match, they can be used.
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