硝苯地平片所致急性泛发性发疹性脓疱病的临床特点

摘要

Objective To summarize the clinical features of acute generalized anthematous pustulosis caused by taking nifedipine tab-letsorally,and to further provide a reference for timely diagnosis and treatment.Methods Weretrospectivelyanalyzedthecaseofa patient who contracted acute generalized anthematous pustulosis caused by taking nifedipine tablets orally on May 2014.The existing lit-erature was reviewed to summarize the clinical features of acute generalized anthematous pustulosis caused by taking adalat orally.Re-sults There were totally two case reports about acute generalized anthematous pustulosis caused by nifedipine tablets and the incuba-tion period was 3 days.The rash started from the trunk and limbs,and the typical skin lesion was small non-follicles (diameter usually<5 mm)generalized aseptic pustules on edema erythema.The key to treatment was to stop taking nifedipine tablets.Antiallergics (lo-ratadine tablets or cetirizine)and antipyreticscould be applied to mild patients,while glucocorticoids should be used as soon as possible among severe patients which could achieve better prognosis.Conclusions The acute generalized anthematous pustulosis caused by nifedipine tablets is rare,which is difficult to identify,but the prognosis is good.%目的 总结口服硝苯地平所致急性泛发性发疹性脓疱病的临床特点,为临床及时发现及时处理提供参考.方法 回顾性分析1例口服硝苯地平致急性泛发性发疹性脓疱病病人,对已有文献报道进行分析,总结口服硝苯地平所致急性泛发性发疹性脓疱病的临床特点.结果 硝苯地平所致的急性泛发性发疹性脓疱病,潜伏期3 d,皮疹可起始于躯干和四肢,水肿性红斑上的非毛囊性小的(直径通常<5 mm)泛发的无菌性脓疱是其典型的皮损特征.治疗上及时暂停硝苯地平是关键,轻症给予抗过敏药物(氯雷他定片或西替利嗪)和对症退热药,重症应及早应用糖皮质激素,预后较好.结论 硝苯地平所致急性泛发性发疹性脓疱病极少见,常不易识别,预后较好.