Objective To explore the characteristics of decision-making impairment in alcohol-dependence patients. Methods A total of 18 individuals with alcohol-dependence were compared with matched health controls on the Iowa gambling task ( IGT ). Results In Iowa gambling task, the results showed that alcohol-dependence patients selected more disadvantageous cards than health controls, however without significant difference[ ( 46. 67 ± 6. 72 vs 46. 45 ± 12. 28 respectively ), t = 0. 07 ,P > 0. 05 ]. A 2 ( group ) × 5 ( block ) ANOVA ( analysis of variance ) on the scores of advantageous from the gambling task revealed a significant main effect of block [ F( 0. 529 ) = 3. 929 ,P 0.05].采用2(组)×5(阶段)的方差分析比较两组不同阶段的总有利选择:结果发现不同阶段主效应显著[F(0.529)=3.929,P<0.05];而被试组别主效应[F(0.001)=0.01,P=0.92]和两者的交互作用[(F(0.333)=1.74,P=0.196)]差异无统计学意义.两组被试5个阶段的净得分两两比较显示:对照组在81~100张(block5)的净得分显著高于酒精依赖组(P<0.05).结论 酒精依赖患者IGT表现受损,可能与眶额叶皮质、杏仁核受损以及多巴胺功能障碍有关.
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