物理刺激诱导的治疗通常是利用多功能诊疗试剂对外界物理刺激,如光、磁场、超声、射频以及X射线等的响应性进行治疗的策略.近年来,这种新颖的癌症治疗方法在临床前期的动物实验组取得了良好的实验结果,因而该策略也备受关注.与传统的化疗疗法不同,物理刺激响应性的试剂本身通常是无毒性的,只有在特定的物理刺激之下才会在病灶部位产生治疗效果.此外,物理刺激诱导的治疗方法还可以与传统治疗策略结合,通过不同的机制达到协同治疗的目的.在这篇综述中,我们将阐述物理刺激诱导治疗的最新发展动态,并深入讨论纳米诊疗试剂在该治疗策略中的重要作用.%Multifunctional theranostic agents that are responsive to external physical stimuli such as light, magnetic field, ultrasound, radiofrequency, and X-rays have been widely explored for their use in physical stimulus-responsive therapies for cancer. Encouraging results in many preclinical animal experiments have been obtained; thus, this innovative strategy has gained great attention. Owing to the nontoxicity of physical stimulus-responsive agents and treatment specificity under particular external stimuli, physical stimulus-responsive cancer therapies provide greatly reduced toxicity and enhanced therapeutic efficiency compared with conventional chemotherapeutic agents. When combining physical stimulus-responsive therapies with other traditional therapeutics, synergistic antitumor effects via various mechanisms can be achieved. In this review, we will summarize the recent developments in physical stimulus-responsive therapies and discuss the important roles of nanoscale theranostic agents in these novel treatment modalities.
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