神经元网络中分布式电流诱导靶波机理研究

摘要

The formation of target wave in the network of Hodgkin-Huxley neuron with four variables is investigated by inputing a distribuled current. A stimulus current (I1) is input in to a local square area, and another stimulus current (I2) is input into the nodes of the network thus the distributed current is depicted. The development of target wave is measured by changing the coupling intensity, the size (number of the controlled neurons) of the local area into which current I1 is input, the gradient current (∆I=I1−I2). It is found that higher gradient current (∆I) is necessary to induce target wave when local area into which current I1 is input is smaller in size and the coupling intensity is higher in value. Finally, the potential mechanisms of the stimulus current and target wave formation are discussed in brief. Eextensive numerical results confirm that the developed target wave is robust to a certain channel noise.%　　以四变量的Hodgkin-Huxley神经元模型构建规则网络来研究分布式电流刺激诱导靶波问题。在一个二维规则网络的局部方形区域输入恒定刺激电流I1,其余区域结点上的神经元输入刺激电流I2来刻画分布式电流。分别研究了耦合强度、刺激电流I1作用区域(受控神经元个数)、分布式电流梯度(∆I=I1−I2)对靶波形成的影响。研究发现：刺激的区域越小,需要的电流梯度(∆I)越大；耦合强度越大,诱导靶波所需要的电流梯度(∆I)也越大。最后讨论了分布式电流作用和靶波的形成机理。进一步研究发现,诱导的靶波对通道噪声有较强的抗干扰性。