白念珠菌钙稳态系统及钙信号途径的研究进展

摘要

白念珠菌是临床重要的条件致病菌,其胞内的钙稳态及钙信号途径与宿主侵染、压力应答等诸多生理过程紧密相关.研究该菌的钙稳态系统及钙信号调控网络,对明确白念珠菌的侵染机制与耐药机理,以及开发具有新靶点的抗真菌药物具有重要意义.本文对这些内容的研究进展进行了综述.%Candida albicans is one of the most important conditional pathogens. Calcium homeostasis systems and calcium signaling in this pathogen are closely associated with numerous physiological processes, such as pathogenesis and stress responses. Study on calcium homeostasis systems and calcium signaling pathways will illuminate its calcium-related mechanisms of pathogenesis and drug resistance, and establish new therapeutic strategies for fungal infections. This review introduced the advances in the study in these fields.